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PREreviews de Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer’s knock-in mouse phenotypes

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  1. par Fisher Cherry et 1 autre auteur du HHMI Transparent and Accountable Peer Review Training Program

    Summary

    A growing body of work suggests that metabolic dysfunction, such as diabetes mellitus, can aggravate the cognitive decline of patients with Alzheimer’s disease (AD); however, the molecular basis for the overlap in metabolic dysfunction in both Alzheimer’s and diabetes mellitus is…

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  2. par Yan Li et Huda Zoghbi du HHMI Transparent and Accountable Peer Review Training Program

    In this manuscript, Nicholson et al. investigated whether hyperglycemia caused by decreased insulin vs insulin resistance drives AD pathology. The interest in addressing this question stems from the observation that type 2 diabetes and people with metabolic syndrome (MetS) show early onset of…

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  3. par Xue Deng du HHMI Transparent and Accountable Peer Review Training Program

    In this manuscript, Nicholson et al., investigate how systemic metabolic dysfunction alters brain function in Alzheimer’s disease (AD). Building on prior evidence that both hyperglycemia and insulin signaling deficits contribute to AD risk, a key question addressed by this study is whether it is…

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