Avaliações PREreview de Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer’s knock-in mouse phenotypes

3 Avaliações PREreview

1. Avaliação PREreview feita por Fisher Cherry et al. do/a HHMI Transparent and Accountable Peer Review Training Program

   De autoria de Fisher Cherry e 1 outro autor do/a HHMI Transparent and Accountable Peer Review Training Program

   Summary

               A growing body of work suggests that metabolic dysfunction, such as diabetes mellitus, can aggravate the cognitive decline of patients with Alzheimer’s disease (AD); however, the molecular basis for the overlap in metabolic dysfunction in both Alzheimer’s and diabetes mellitus…

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2. Avaliação PREreview feita por Yan Li et al. do/a HHMI Transparent and Accountable Peer Review Training Program

   De autoria de Yan Li e 1 outro autor do/a HHMI Transparent and Accountable Peer Review Training Program

   In this manuscript, Nicholson et al. investigated whether hyperglycemia caused by decreased insulin vs insulin resistance drives AD pathology. The interest in addressing this question stems from the observation that type 2 diabetes and people with metabolic syndrome (MetS) show early onset of…

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3. Avaliação PREreview feita por Xue Deng do/a HHMI Transparent and Accountable Peer Review Training Program

   De autoria de Xue Deng do/a HHMI Transparent and Accountable Peer Review Training Program

   In this manuscript, Nicholson et al., investigate how systemic metabolic dysfunction alters brain function in Alzheimer’s disease (AD). Building on prior evidence that both hyperglycemia and insulin signaling deficits contribute to AD risk, a key question addressed by this study is whether it is…

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