Facile discovery of isonitrile natural products via tetrazine based click reactions
Escrito por Yaobing Huang, Wenlong Cai, Antonio Del Rio Flores, Frederick Twigg y Wenjun Zhang
Publicada
Servidor
bioRxiv
DOI
10.1101/711853
A facile method for the quick discovery and quantification of isonitrile compounds from microbial cultures was established based on the isonitrile-tetrazine click reaction. A in situ reduction further enabled bioorthogonal ligation of primary and secondary isonitriles for the first time.
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