Facile discovery of isonitrile natural products via tetrazine based click reactions
Authored by Yaobing Huang, Wenlong Cai, Antonio Del Rio Flores, Frederick Twigg, and Wenjun Zhang
Posted
Server
bioRxiv
DOI
10.1101/711853
A facile method for the quick discovery and quantification of isonitrile compounds from microbial cultures was established based on the isonitrile-tetrazine click reaction. A in situ reduction further enabled bioorthogonal ligation of primary and secondary isonitriles for the first time.
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