A wheat tandem kinase sensor activates an NLR helper to trigger immunity
Escrito por Renjie Chen, Jian Chen, Megan A. Outram, Oliver R. Powell, Taj Arndell, Karthick Gajendiran, Yan L. Wang, Michael A. Ayliffe, Cheryl Blundell, Melania Figueroa, Jana Sperschneider, Thomas Vanhercke, Dingzhong Tang, Yang Xu, Guitao Zhong, Catherine Gardener, Guotai Yu, Spyridon Gourdoupis, Łukasz Jaremko, Oadi Matny, Brian J. Steffenson, Willem H. P. Boshoff, Wilku B. Meyer, Stefan T. Arold, Peter N. Dodds y Brande B. H. Wulff
Publicada
Servidor
bioRxiv
DOI
10.1101/2024.08.30.610287
Most plant resistance genes encode membrane-anchored receptor-like proteins or intracellular nucleotide-binding and leucine-rich repeat (NLR) receptors. In wheat and barley, tandem kinases (TKs) have emerged as a new class of resistance determinants. To understand the modus operandi of the wheat stem rust resistance protein Sr62TK, we identified two genetic interactors— a host gene required for Sr62TKfunction and the corresponding fungal AvrSr62 effector. We discovered that theSR62locus consists of a digenic module encoding Sr62TKand an NLR (Sr62NLR). AvrSr62 binds to the N-terminal kinase of Sr62TK. This triggers displacement of the C-terminal kinase allowing it to recruit Sr62NLRfor activation of immune responses. Understanding the mechanism of this two-component resistance complex will help engineering and breeding for durable resistance.
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