PREreviews of “A wheat tandem kinase sensor activates an NLR helper to trigger immunity”

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A wheat tandem kinase sensor activates an NLR helper to trigger immunity

by Renjie Chen, Jian Chen, Megan A. Outram, Oliver R. Powell, Taj Arndell, Karthick Gajendiran, Yan L. Wang, Michael A. Ayliffe, Cheryl Blundell, Melania Figueroa, Jana Sperschneider, Thomas Vanhercke, Dingzhong Tang, Yang Xu, Guitao Zhong, Catherine Gardener, Guotai Yu, Spyridon Gourdoupis, Łukasz Jaremko, Oadi Matny, Brian J. Steffenson, Willem H. P. Boshoff, Wilku B. Meyer, Stefan T. Arold, Peter N. Dodds, and Brande B. H. Wulff

Posted: August 30, 2024
Server: bioRxiv
DOI: 10.1101/2024.08.30.610287

Abstract

Most plant resistance genes encode membrane-anchored receptor-like proteins or intracellular nucleotide-binding and leucine-rich repeat (NLR) receptors. In wheat and barley, tandem kinases (TKs) have emerged as a new class of resistance determinants. To understand the modus operandi of the wheat stem rust resistance protein Sr62^TK, we identified two genetic interactors— a host gene required for Sr62^TKfunction and the corresponding fungal AvrSr62 effector. We discovered that theSR62locus consists of a digenic module encoding Sr62^TKand an NLR (Sr62^NLR). AvrSr62 binds to the N-terminal kinase of Sr62^TK. This triggers displacement of the C-terminal kinase allowing it to recruit Sr62^NLRfor activation of immune responses. Understanding the mechanism of this two-component resistance complex will help engineering and breeding for durable resistance.

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PREreview by AmirAli Toghani et al. of the TSL Preprint Club

Authored by AmirAli Toghani, Sophien Kamoun, Josh Bennett, and 4 other authors of the TSL Preprint Club

General Remarks
In wheat and barley, tandem kinases (TKs) have emerged as a significant class of resistance determinants. Chen et al. previously cloned the TK Sr62TK and here they show it relies on a genetically linked NLR immune protein, Sr62NLR, to function. They propose a model in which the…

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PREreviews of A wheat tandem kinase sensor activates an NLR helper to trigger immunity

1 PREreview

General Remarks