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PREreview of Probing the modulation of enzyme kinetics by multi-temperature, time-resolved serial crystallography

by James Fraser

Published: September 23, 2024
DOI: 10.5281/zenodo.13826411
License: CC BY 4.0

This is an excellent experimental setup and I read the manuscript with great interest. My major question has to do with the modeling in Figure 2. Is there no solvent in any of the substrate/product states or an apo state that needs to be modeled in the active site. This seems like it might have a major effect on the estimated occupancies.

Competing interests

The author declares that they have no competing interests.

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