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The Omega.limit theory proposes that each biological system has a critical energy transition rate, beyond which cellular homeostasis breaks down. This threshold is defined as Omega.limit = λ × Ω, where Ω ≈ 1.5762 and λ is a tissue-specific energy tolerance coefficient. This document presents a comparative analysis of theoretical Omega.limit values versus experimentally observed dE/dt in various cancer types, incorporating references to recent clinical and experimental findings. The author acknowledges the use of OpenAI’s language model for assistance in drafting certain sections of this workl