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Background: Human papillomavirus (HPV) vaccination is a major strategy for cervical cancer prevention, but uptake may be affected by misinformation, sociocultural concerns, and distrust. Pakistan’s 2025 national HPV vaccine rollout provided an opportunity to explore how parents experienced and interpreted this new intervention. Methods: A phenomenological qualitative study explored parental experiences in Islamabad and Rawalpindi through 16 in-depth interviews conducted in Urdu during September and October 2025. Data were transcribed, translated, coded using NVivo-supported procedures, and analysed thematically using Braun and Clarke’s reflexive approach. Interpretation integrated the Socio-Ecological Model and WHO health-system building blocks. Results: Parents initially described fear, uncertainty, infertility concerns, misinformation, moral concerns, and distrust of institutions. Islamabad participants reported greater exposure to digital information and misinformation and sought formal evidence and professional reassurance. Rawalpindi participants relied more strongly on interpersonal reassurance from Lady Health Workers, teachers, relatives, and other parents. Across settings, confidence increased when concerns were acknowledged, information was communicated clearly, vaccination appeared safe, and trusted community members endorsed the intervention. Conclusion: HPV vaccine confidence is relational and context-dependent. Successful implementation requires transparent communication, trained frontline workers, community engagement, rapid misinformation response, and visible institutional accountability.