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Many companies are re-examining their integration architectures as the pace of Digital Transformation in enterprise E-Commerce (B2B and B2C) accelerates. New integration architectures will depend on the ecosystem of services offered by partners. Integration patterns, including API-led connectivity and Pub-Sub messaging, have become essential in implementing such changes. This paper details a comparative study of two API orchestration paradigms synchronous request-response and asynchronous event-driven using MuleSoft Platform. This paper provides an example of the orchestration and reusability capabilities of the MuleSoft platform. The paper assesses several factors scalability, resilience, resource usage, and operational expenses and the influence of each orchestration model. The paper brings to the fore the performance trade-offs of each of these strategies using production deployment benchmark and industry-reported data: Thread-blocking constraints of synchronous systems. Eventual-consistency issues of an asynchronous messaging system. Trade-offs of point-to-point integration architecture. Thus, we can conclude that asynchronous integration architecture is applicable for the organizations where same data must be sent to multiple different downstream systems. Also, synchronous integration is useful where real time processing is needed for the end user. Research introduces a decision roadmap for integration architects to navigate modernization programs. Based on the business context and significance of the service, hybrid orchestration will create the most scalable and cost-effective results. This research was also conducted on the real production deployed applications using API-LED architecture pattern (experience layer, process layer and system layer) and evaluated 14M+ transactions in production system.