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Background: While Behavioral Activation (BA) is a validated and widely used treatment for depression, a subset of cases exhibits a paradoxical failure: patients demonstrate insight, express motivation, and engage in therapy but fail to initiate any behavioral change. Existing behavioral and cognitive models offer limited structural explanations for such ignition failure. Objective: This paper applies Cognitive Drive Architecture (CDA), an emerging structural field grounded in Lagunian Dynamics and governed by Lagun’s Law of Primode and Flexion Dynamics, to reinterpret a well-documented BA treatment failure. The goal is not to critique BA but to examine whether ignition failure may reflect deeper architectural misalignment rather than motivational deficit. Method: Using secondary analysis, the clinical case of “Karen” (Hopko et al., 2011) is reinterpreted through the CDA framework. Six structural variables (Primode, CAP, Flexion, Anchory, Grain, and Slip) were mapped to observed behaviors, therapeutic responses, and contextual factors. Latent Task Architecture (LTA), a domain-specific extension of Lagunian Dynamics, is used to model task readiness and resistance layering. Results: Karen’s persistent non-initiation is structurally explained by a configuration of near-zero Primode, low CAP, poor Flexion, weak Anchory, high Grain, and minimal Slip. This Drive profile mathematically predicts near-zero behavioral output despite motivation or understanding, resolving the paradox without pathologizing the patient. Conclusion: CDA reframes treatment nonresponse not as resistance or noncompliance, but as a predictable structural outcome under specific internal configurations. This suggests a future direction in which therapeutic approaches are selected based on drive architecture assessment rather than symptom profiles alone. Implications for pre-intervention calibration, clinical modeling, and the structural classification of treatment resistance are discussed.