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Metallogels—three-dimensional supramolecular networks formed through metal–ligand coordination—have emerged as a new generation of adaptive soft materials with promising biomedical potential. By integrating the structural stability and tuneable functionality of metal centres with the dynamic self-assembly of organic gelators, these systems exhibit exceptional mechanical strength, responsiveness, and multifunctionality. Recent studies demonstrate their diverse applications in drug delivery, anticancer therapy, antimicrobial and wound healing treatments, biosensing, bioimaging, and tissue engineering. The coordination of metal ions such as Ru(II), Zn(II), Fe(III), and lanthanides enables the creation of self-healing, thixotropic, and stimuli-responsive gels capable of controlled release and therapeutic action. Moreover, the incorporation of luminescent or redox-active metals adds optical and electronic properties suitable for diagnostic and monitoring purposes. This collection summarizes the most recent advances in the field, highlighting how rational molecular design and coordination chemistry contribute to the development of multifunctional, biocompatible, and responsive metallogels that bridge the gap between materials science and medicine.