Background/Objectives: Pressure ulcers are an important patient safety healthcare concern. While staging frameworks guide clinical management, the association of the anatomical site, stage, and multiple PU presence, with outcomes such as length of stay (LOS) and mortality in Medicare patients has not been fully characterized. The study objective is to examine the relationship between PU site, stage, and multiplicity with inpatient LOS and mortality among hospitalized Medicare patients. Methods: This cross-sectional study was conducted with 1,123,121 inpatient Medicare admissions from a CMS medical claims dataset. PUs were identified using ICD-10-CM codes, classified by anatomical site and stage (1 though 4, unstageable, unspecified). Multivariate models examined associations of PU characteristics with LOS and mortality, adjusting for age, sex, primary diagnosis, and hospital transfer. Results: Overall, 3.7% of admissions included at least one PU (n=41,525). Stage 2 ulcers were the most common (28.6%), while unstageable or unspecified ulcers were frequent in heels and head. The sacral region was the most common anatomical site, followed by buttocks and heels. LOS gradually increased from Stage 1 (9.4 days) to Stage 4 (15.2 days). While death rate did not increase consistently with stage, it was highest for upper back (14%), head (12.8%), and unspecified hip (12.8%) sites. Multivariate analyses found sacral, hip, head, buttock, upper back ulcers and ulcers to be associated with prolonged LOS and increased mortality. Conclusions: PU anatomical site and multiple PU presence were stronger predictors of adverse outcomes than stage alone. These findings emphasize the importance of systematic documentation, early detection, and patient safety protocols to reduce the clinical and systemic burden of PUs.