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This study focuses on the development and characterization of an antimicrobial dental gel using natural ingredients, including neem extract, clove oil, honey, and vitamin E. Three gel formulations (F1, F2, and F3) were prepared with varying concentrations of these ingredients and evaluated for their antimicrobial activity, pH, viscosity, spreadability, and skin irritation potential. The results showed that all formulations exhibited antimicrobial activity against Streptococcus mutans, with F3 demonstrating the most significant activity. F3 had a pH of 7.0, viscosity of 9632 cps, and spreadability of 26.08. The study suggests that the F3 formulation holds potential for development as a natural, plant-based oral gel for managing and preventing oral infections.