Malaria remains a significant public health challenge in Bangladesh, driven by a complex interplay of environmental determinants and occupational exposure. This paper explores the climatic and anthropogenic factors influencing malaria transmission dynamics, including temperature, humidity, rainfall, deforestation, urbanization, and agricultural practices. Seasonal variations, particularly during monsoons, create ideal conditions for mosquito proliferation, exacerbating the risk of outbreaks. High-risk occupational groups, such as agricultural workers, forest laborers, and construction workers, face disproportionate exposure due to their prolonged time in vector-rich environments. The analysis underscores the need for integrated malaria control strategies that incorporate environmental management and targeted occupational health interventions. Recommended measures include improved vector control, sustainable land-use policies, protective equipment for workers, and enhanced health education programs. By addressing these environmental and occupational determinants, policymakers can strengthen disease prevention efforts and mitigate the socio-economic burden of malaria in Bangladesh.