The present mini-review on the general and specific aspects of the Platelet-rich-fibrin (PRF) application technique adopted for dermatological treatments reports differences between Platelet-rich plasma (PRP) and PRF, their specific applications in dermatology and preparation methods, mainly with respect to PRF. The protocol for patients undergoing treatment and the ethical aspects that must be addressed by treatment specialists, such as the informed consent, is also highlighted. Clinical trials have proven i-PRF (injectable platelet-rich fibrin) to be more effective than PRP in skin regeneration. The i-PRF method accounts for a more sustaining and long-lasting release of growth factors (GFs). Furthermore, it proved more effective in most studies in comparison with PRP. Therefore, it is now acknowledged for its several medical and dermatological applications. Finally, PRP and PRF use seems promising given their favorable, safe, and well-tolerated results in improving facial aging signs.