Avaliações PREreview de “Uncovering the hidden antibiotic potential of Cannabis”

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Uncovering the hidden antibiotic potential of Cannabis

de Maya A. Farha, Omar M. El-Halfawy, Robert T. Gale, Craig R. MacNair, Lindsey A. Carfrae, Xiong Zhang, Nicholas G. Jentsch, Jakob Magolan e Eric D. Brown

Publicado: 7 de novembro de 2019
Servidor: bioRxiv
DOI: 10.1101/833392

Resumo

The spread of antimicrobial resistance continues to be a priority health concern worldwide, necessitating exploration of alternative therapies. Cannabis sativa has long been known to contain antibacterial cannabinoids, but their potential to address antibiotic resistance has only been superficially investigated. Here, we show that cannabinoids exhibit antibacterial activity against MRSA, inhibit its ability to form biofilms and eradicate pre-formed biofilms and stationary phase cells persistent to antibiotics. We show that the mechanism of action of cannabigerol is through targeting the cytoplasmic membrane of Gram-positive bacteria and demonstrate in vivo efficacy of cannabigerol in a murine systemic infection model caused by MRSA. We also show that cannabinoids are effective against Gram-negative organisms whose outer membrane is permeabilized, where cannabigerol acts on the inner membrane. Finally, we demonstrate that cannabinoids work in combination with polymyxin B against multi-drug resistant Gram-negative pathogens, revealing the broad-spectrum therapeutic potential for cannabinoids.

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Avaliação PREreview de Craig McCormick

De autoria de Craig McCormick

We, the students of MICI5029/5049, a Graduate Level Molecular Pathogenesis Journal Club at Dalhousie University in Halifax, NS, Canada, hereby submit a review of the following BioRxiv preprint:
Maya A. Farha, Omar M. El-Halfawy; Robert T. Gale; Craig R. MacNair; Lindsey A. Carfrae; Xiong Zhang,…

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Avaliações PREreview de Uncovering the hidden antibiotic potential of Cannabis

1 Avaliação PREreview