Cytokine profile of saliva in adults with focal enamel demineralization after orthodontic treatment
- Publicado
- Servidor
- medRxiv
- DOI
- 10.1101/2025.11.19.25340370
Background and aim
the saliva content and correlation with the intensity of caries of proinflammatory cytokines IL-1ß, IL-6, IL-8 and anti-inflammatory cytokines IL-4 and IL-10 were studied in patients with FED after long-term orthodontic treatment.
Materials and methods
26 patients aged 18 to 30 years were divided into three groups: a group of patients without caries, a group with compensated caries with a caries intensity index (DMF decayed, missing, filled) value of less than 5.0 and a group with decompensated caries with a caries intensity index value of more than 5.0.
Results
based on the results obtained, it was found that patients with FED have violations both in the system of nonspecific and specific local immunity, which is more pronounced in patients with decompensated caries. The essential role of the proinflammatory cytokine IL-6 was noted, the content of which in saliva significantly prevails in patients with decompensated caries.
Conclusion
the study of the correlation relationships of the studied cytokines allowed us to determine the significant role of IL-6 and IL-4 cytokines and their ratios in the pathogenesis of FED.