Avaliações PREreview de Alveolar metabolite availability facilitates secondary infection by Pseudomonas aeruginosa in acutely injured lungs

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Alveolar metabolite availability facilitates secondary infection by Pseudomonas aeruginosa in acutely injured lungs

de Jennifer M. Baker, Thomas L. Flott, Laura A. McLellan, Ingrid G. Bustos, Jose L. Guerrero, Lina M. Mendez, Annastasia M. Petouhoff, Piyush Ranjan, Joseph D. Metcalf, Roderick A. McDonald, Nicole R. Falkowski, Ying He, Mónica P. Cala, Gary B. Huffnagle, Michael W. Sjoding, Luis F. Reyes, Kathleen A. Stringer e Robert P. Dickson

Publicado: 4 de janeiro de 2025
Servidor: bioRxiv
DOI: 10.1101/2024.12.18.629020

Resumo

Secondary bacterial pneumonia is a frequent complication of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Prior efforts to explain increased pneumonia risk in ALI/ARDS have focused on impaired immunity and bacterial virulence, but have overlooked the potential contribution of ecological factors within acutely injured lungs. Here, we show that lung injury profoundly alters the alveolar metabolic microenvironment, a change that can be exploited by a common pneumonia pathogen. In mice and humans, we found that growth of Pseudomonas aeruginosa (the most prominent respiratory pathogen in a retrospective cohort of patients with ARDS) is enhanced by increased alveolar concentrations of multiple ALI/ARDS-associated metabolites, which are derived from the blood and cross the compromised alveolar-capillary barrier during alveolar leak. Collectively, this work reveals an ecological mechanism by which pathogens may survive in the injured lung microenvironment and identifies new potential targets for secondary pneumonia prevention and treatment.

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Avaliação PREreview de Craig McCormick

De autoria de Craig McCormick

We, the students of MICI5029/5049, a Graduate Level Molecular Pathogenesis Journal Club at Dalhousie University in Halifax, NS, Canada, hereby submit a review of the following BioRxiv preprint:

Alveolar metabolite availability facilitates secondary infection by Pseudomonas aeruginosa in acutely…

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