A voltage-step method for detecting high-frequency transient current components in deep brain tissue: preliminary in vivo measurements in rats
Rédigé par Sultan Mahmud , Domenica Baez , Anyu Jiang , Yitong Zhao , Baibhab Chatterjee , Adam Khalifa et Chris Rourk
Publié 8 juillet 2026
Serveur de preprints bioRxiv
Résumé
A test technique for measuring high-frequency transient current components in deep brain tissue is presented. The technique applies a voltage pulse with a high value in dV/dt, generating a corresponding current pulse with high dI/dt that can elicit measurable transient current responses from the electrode–tissue interface and adjacent brain tissue; responses are analyzed in the frequency domain by Fast Fourier Transform at a 200 kHz sampling frequency. The method was motivated by prior evidence that ferritin and neuromelanin in catecholaminergic tissue may support high-frequency conduction properties that have not previously been characterized in vivo. The protocol was applied in 277 measurements across five Sprague Dawley rats at cortical and basal ganglia locations in different locations in the brain. Preliminary spectral results show differences between catecholaminergic regions and cortical tissue that support further development and validation of the method.
Lire le preprint