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One-dimensional fibrous scaffolds with tunable bioactivity offer promise for bone tissue regeneration, yet optimal calcium phosphate phases for enhancing osteogenic perfor-mance remain underexplored. This study aimed to evaluate the impact of monetite, brushite, and cerium-doped phosphates deposition on electrospun nylon nanofibres func-tionalized via matrix-assisted pulsed laser evaporation (MAPLE). Six nylon fibre composi-tions were synthesized, coated with three calcium phosphate phases, calcined at varying temperatures (500–800 °C) before laser deposition. Physicochemical properties were as-sessed using energy-dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), and fibre diameter measurements. Biocompatibility assays following MC3T3 pre-osteoblast seeding and incubation evaluated biological performance. EDX confirmed homogeneous phase deposition; SEM showed phase- and temperature-dependent mor-phology, with monetite yielding uniform granular structures and cerium-doped phos-phate at 800 °C forming dense aggregates. Brushite-coated fibres exhibited superior preos-teoblast metabolic activity versus monetite variants, indicating phase-specific stimulation of bone cells growth. These phosphate-functionalized nylon fibres retain structural integ-rity, hierarchical porosity, and enhanced bioactivity, providing a versatile electrospin-ning-MAPLE platform for customizable bone grafts with clinical potential.