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A Comprehensive Review of Plant Peptide Databases for Peptidomic and Therapeutic Research

Publié
Serveur de preprints
Preprints.org
DOI
10.20944/preprints202604.1610.v1

The bioactive plant peptides represent a significant and yet largely underexploited resource with huge potential not only for basic plant science but also for various biotechnological applications, including pharmaceutical and agrochemical development. bioactive plant peptides represent a significant and yet largely underexploited resource with huge potential not only for basic plant science but also for various biotechnological applications, including pharmaceutical and agrochemical development. This fastexpanding research area of plant peptidomics demands the creation and continuous updating of dedicated databases that facilitate data integration of heterogeneous nature and enable efficient knowledge discovery. The most representative databases, like PlantPepDB and PhytAMP, but also recent multi-purpose databases like MFPPDB, are reviewed here in terms of data sources used-literature and public repositories-manual curation extent, functional classification-such as therapeutic, defense, and inhibitory-and the availability of relevant metadata on physicochemical properties and structure. While databases focused on specific bioactivities of plant peptides offer high-quality, focused data, broader repositories are crucial for discovering multifunctional peptides and structure-activity relationships. The refinement and integration of these databases, alongside advanced bioinformatics tools, remain essential for overcoming these hurdles. These resources stand to facilitate innovation in ways that will continue to illuminate insights into the molecular function of plants and allow the successful harnessing of plant peptides toward human health improvements and sustainable agriculture. This review briefly introduces the progress of plant peptide research, presents an overview of plant peptide studies, and provides a comprehensive analysis of existing plant peptide databases, evaluating their scope, content, and utility. We anticipate that this work will bridge the gap between peptide discovery and the development of nextgeneration plant peptide databases.

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