Opposing historical nihilism is an important proposition that runs through the century-long ideological struggle of the Communist Party of China. As an erroneous trend that denies the achievements of China's revolution, construction, and reform, historical nihilism has long been highly vigilant and continuously criticized by the Communist Party of China. Based on methods such as literature analysis and historical evidence verification, this paper analyzes the origins and evolution of historical nihilism, traces the Party's practical journey in opposing historical nihilism during the New Democratic Revolution period, the Socialist Revolution and Construction period, and the Reform and Opening-up new era, and reveals the theoretical responses and practical innovations of Chinese Communists in the new era against historical nihilism.