Background: The Induced Membrane Technique (IMT), often referred to as the Masquelet Technique (MT) can be used to achieve excellent results in the reconstruction of bone defects due to osteomyelitis. However, this is not a defined surgical technique, but a treatment option that has undergone several modifications since it was first described and with heterogeneous results. Methods: This retrospective, monocentric cohort study included 49 patients treated with the Bone Block Technique (BBT) between 2013 and 2019 with bone defects due to osteomyelitis. The primary outcome was time to bony healing, reinfection rate and time to full-weight bearing. Additionally, infectiology parameters, surgical site complications (SSC) and epidemiological data were assessed. Results: The complete data records of 49 patients were analyzed. Mean patient age was 51 years (17.6-76.9 years) with 14 being female (28.6%) and 35 male (71.4%). Mean follow-up was 6.1 years (4-10.5 years). Average bone defect length was 4.2 cm (2.1- 8.4 cm) with the majority of defects affecting the lower extremity. Primary consolidation was achieved in 93%, secondary consolidation (additional surgery) in 7%. Eight patients (16.6%) needed revision surgery due to recurrent infection. Full weight bearing could be achieved after 101.3 days on average. Conclusion: The BBT as a modification of the original IMT, is a valid alternative approach in the reconstruction of bone defects. With correct application of the technique described here and adherence to the principles of the Diamond Concept primary consolidation and low complication rates can be achieved, making the technique reliable and reproducible.