Tannery is the place where higher putrescible outer cover rings of animals are converted into non putrescible leathers with improved physical, chemical and biological properties. From 2017, around 155 tanneries were moved to the Savar Tannery Industrial Estate. Approximately 40 small tanneries were not able to such relocation and unfortunately, stopped their operations [Akhi Akter-2018]. There are around nine lakhs’ peoples who are involved directly or indirectly with the leather sector [The Daily Jugantor]. The workers are the heart of the industries. They play a vital role in the development of the leather industry. But most of the workers are uneducated and unconscious about the health safety. Moreover, they have little knowledge about the chemicals they use. Some chemicals are toxic, some are hazardous, some are flammable, corrosive etc. This survey shows the problems they face during the use of various chemicals in leather processing and their preventive measures. If the workers feel physical illness or weakness, they don’t have the time to recover from it. As they don’t have proper knowledge about the chemicals, they are not aware of the risk and safety precautions. This study tries to know about the risks involved in the leather industry, chemicals used in manufacturing process in the tanneries, about the hazardous chemicals, their effects on human body and their preventive measures in leather industries.