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Background: Concentrated deep seawater is rich in minerals, including magnesium (Mg), sodium (Na), potassium (K), and calcium (Ca), commonly used in multivitamin. When these minerals are served as solid forms, their nature are highly hygroscopic, making them prone in absorbing moisture. Consequently, development of a non-hygroscopic solid dosage form derived from mineral-rich concentrated deep seawater is highly in need. Methods: Prior formulation stage, the quality of the deep seawater was verified through physical, chemical, and biological assessments based on available Quality Standard. To provide solid form with moisture resistance, the deep seawater concentrate was formulated into granule by using fillers: Avicel® PH 102 and Lactose with 10% Florite® as dessicant. Comprehensive evaluations of the granules including organoleptic, physical properties such as Flow rate, Angle of repose, Compressibility and Loss on Drying had been conducted. These parameters were also evaluated during stability study for five months of storage. Advance verifications were also been performed by using instruments such as Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Scanning Electron Microscopy (SEM). Results: The results indicated that the optimum moisture protection was provided by granule formulation using Avicel® PH 102 as filler (G-Av) either with or without addition of Florite® 10%. Stability study showed that the protection was effective either in ambient temperature or climatic chamber storage. Conclusions: Avicel PH 102 as filler provided moisture protection for deep seawater granules which highly hygroscopic in nature.