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Does the introduction explain the objective of the research presented in the preprint?

Yes

The authors wrote a comprehensive introduction on CVD and edentulism based on previous studies. They highlighted the gaps in the literature and properly justified the study in filling in the gaps. However, we are of the view that edentulism should have been clearly defined for the readers to easily comprehend.

Are the methods well-suited for this research?

Somewhat appropriate

The study design was appropriate for the analysis. They used appropriate statistical tools and methods for the analysis; however, we identified minor errors that we recommend they address. 2.4 The Potential Confounding Variable Under this section, the sentence "...was classified as a binary variable (male or female)" is incomplete. It should properly start with "Sex." Also under race, the authors should describe what "other race" means or stands for. Otherwise, they should be listed in the appendix.

Are the conclusions supported by the data?

Highly supported

The conclusions of the paper are sound and comprehensive. They made recommendations to relevant stakeholders, such as clinicians and policymakers, to adopt enhanced dental care services and also for them to collaborate with funding agencies to support dental and CVD care.

Are the data presentations, including visualizations, well-suited to represent the data?

Highly appropriate and clear

For the kind of data and analysis strategy they adopted, the representation of their result, which they used tables was appropriate.

How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research?

Very clearly

The authors clearly discussed their results and compared their results with previous studies, either supporting or contrasting findings in line with their results. They recommended a longitudinal study to properly understand the causal relationship between CVD risk and edentulism.

Is the preprint likely to advance academic knowledge?

Highly likely

Yes, the study has expanded our understanding of the relationship between CVD and edentulism.

Would it benefit from language editing?

Yes

Minor grammatical errors and subject-verb agreements were detected. Addressing these could enhance the readability of the paper.

Would you recommend this preprint to others?

Yes, it’s of high quality

Yes, the paper is of high quality. It sheds light on the relationship between CVD and edentulism. It made relevant recommendations to stakeholders to help enhance dental care services.

Is it ready for attention from an editor, publisher or broader audience?

Yes, after minor changes

We recommend that the title of the paper be refined a bit. Suggested title: "The Association between Cardiovascular Disease and Complete Edentulism in a Population of Nationally Represented Adults in the United States of America: A Retrospective Study." We recommend that some minor grammatical errors be addressed. In the introduction, the authors should clearly define edentulism.

Competing interests

The authors declare that they have no competing interests.