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The framework of cascading medicine is proposed as a systemic protocol where treatment is not seen merely as a linear temporal sequence of phases but as an interconnected architecture. In such an architecture, each link performs its own function—weakening external factors, preparing the microenvironment, delivering the main strike, consolidation, and surveillance—and simultaneously creates conditions for the subsequent stage. Thus, therapy is transformed from a set of disparate actions into a holistic dynamic circuit, where success is determined not by the strength of a single intervention, but by the consistency of the entire cascade chain. This allows simultaneous reduction of pathological load, compensation of patient risks, and support of target organs, ensuring a transition from temporary palliation to sustainable outcomes.

Author’s related hypotheses applying the cascade concept:

1. Novruzov, M., Raval, K., & Shiraliyeva, U. (2025). "Second Breath" (Preclinical Hypothesis, in silico validated): Biomarker-Guided Local Immune Sequencing for Desmoplastic Tumors. Zenodo. https://doi.org/10.5281/zenodo.17196703

2. Novruzov, M., & Shiraliyeva, U. (2025). "OXIDOME": A CASCADE APPROACH TO ENHANCING THE ACTION OF ANTIBIOTICS AND PREVENTING RESISTANCE. Zenodo. https://doi.org/10.5281/zenodo.17183639

3. Novruzov, M. (2025). Resurgo Protocol: Non-surgical Rehabilitation for Compression-Ischemic Neuropathy (Radial Nerve Injury). Zenodo. https://doi.org/10.5281/zenodo.16787979