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Bird strike events on rotating jet engine fan blades pose significant risks to aviation safety, yet high-fidelity numerical simulations remain computationally expensive, limiting their use in parametric design studies. This study develops a physics-informed machine learning surrogate framework for predicting bird strike response on rotating Ti-6Al-4V fan blades, systematically comparing Lagrangian (gelatin-based, Mooney–Rivlin) and Smoothed Particle Hydrodynamics (SPH, water-like) formulations. A total of 100 explicit dynamic simulations were conducted in ANSYS LS-DYNA (50 per formulation), varying bird impact velocity and blade angular speed. Random Forest, Support Vector Regression, Polynomial Regression, and XGBoost regression models were trained and evaluated using five-fold cross-validation. Results demonstrate that SPH-based surrogates achieve superior predictive accuracy, with Random Forest yielding R² = 0.9938 for maximum deformation and R² = 0.9962 for total energy dissipation. In contrast, Lagrangian-based stress surrogates exhibited severe performance degradation (R² = 0.24) due to mesh-dependent numerical noise. The trained surrogates achieved computational speed-up factors of 10⁴–10⁵ relative to direct simulation. These findings establish that surrogate model reliability is fundamentally governed by the numerical quality of the training data, providing guidance for integrating machine learning with impact simulation workflows in aero-engine blade design.