Part-time employment is an increasingly important feature of the U.S. labor market, yet little is known about how earnings determinants differ between full-time and part-time pharmacists. Few prior studies have compared earnings models across these groups, but most have relied on small or geographically limited samples. Moreover, the dynamic and rapidly evolving nature of the labor market makes this study especially timely, as most prior research on pharmacist earnings is based on older data. This study examined earnings determination separately for full-time and part-time pharmacists, estimating the influence of work input, human capital, demographic characteristics, and job-related features within each group. Data were drawn from the 2019–2022 American Community Survey (ACS), a large, continuous, nationally representative survey conducted annually by the U.S. Census Bureau. The sample included 12,064 practitioners (4,667 men and 7,397 women) ages 25–64 years practicing in the U.S. Ordinary least-squares equations were estimated separately for male and female practitioners within each employment category, allowing comparison of the direction, magnitude, and statistical significance of covariates across groups. Results revealed notable differences in the earnings effects of several factors between full-time and part-time pharmacists, highlighting the interaction of individual choices and structural market forces in shaping compensation. These findings can inform workforce planning and guide the development of targeted job-related incentives to support retention and satisfaction across employment types.