PREreview of Prevalence of Fatigue Among Inflammatory Bowel Disease Patients at a Tertiary Center in Saudi Arabia

Write a short summary of the research’s main findings and how this work has moved the field forward.

Major issues

• Including healthy controls and stratifying Crohn’s disease patients by ASCA status would enhance the analytical depth by enabling both disease-level comparisons and immunological subgroup characterization

• The cross-sectional design limits causal inference; a longitudinal cohort design would be required to establish temporal relationships and identify true causal risk factors for fatigue.

• The study is subject to several potential biases, including selection bias due to its single tertiary-center setting, recall and response bias from self-reported telephone interviews, and residual confounding from unmeasured variables such as psychological and sleep-related factors

Minor issues

• Timing of laboratory measurements: Greater detail on the temporal proximity between laboratory values and fatigue assessment would improve interpretability.

• Consistency in reporting: Minor inconsistencies in reporting sample sizes across tables and analyses should be standardized for clarity.

Competing interests

The author declares that they have no competing interests.

Use of Artificial Intelligence (AI)

The author declares that they used generative AI to come up with new ideas for their review.