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PREreview of O-GlcNAcylation: A Nutrient-Sensitive Metabolic Rheostat in Anti-Viral Immunity and Viral Pathogenesis

by Mohamed Esmat Mohamed
Published
DOI
10.5281/zenodo.19423635
License
CC0 1.0

Write a short summary of the research’s main findings and how this work has moved the field forward.

Major issues

  • While the review provides a strong overview of the HBP–O-GlcNAc axis in antiviral immunity, it lacks detailed mechanistic validation.

  • Key experimental approaches such as site-directed mutagenesis (e.g., S198A/S198D) are not discussed.

  • Metabolic perturbations like glucose deprivation or 2-DG treatment are also absent. Additionally, AMPK activation and its effect on phase separation are not addressed.

  • The review does not explore protein–protein interactions such as Co-IP with eIF3b. Emerging concepts like YTHDF1 phase separation dynamics are underrepresented despite their relevance.

Minor issues

  • While the review provides a strong conceptual overview of the HBP–O-GlcNAc axis, it lacks quantitative visualization

  • No charts or data-driven figures are included to support or summarize key findings.

Competing interests

The author declares that they have no competing interests.

Use of Artificial Intelligence (AI)

The author declares that they used generative AI to come up with new ideas for their review.