PREreview of Subcellular Localization Constrains Protein Detectability and Reveals Systematic RNA-Protein Discordance Across Cancers

Write a short summary of the research’s main findings and how this work has moved the field forward.

Major issues

• Reliability of protein detectability labels due to IHC/antibody limitations

• Lack of orthogonal validation (e.g., Western blot / proteomics)

• (Possibly) unclear cancer-specific generalization in figures.

Minor issues

• Clarity of feature importance visualization

• Limited discussion of evaluation metrics beyond ROC curves

Competing interests

The author declares that they have no competing interests.

Use of Artificial Intelligence (AI)

The author declares that they used generative AI to come up with new ideas for their review.