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X-ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid based Inhibitors of the SARS-CoV-2 Nsp3 Macrodomain (Mac1)

by Xinyu Wang, William T W Butler, James R Donald, Yuran Wang, Alice L Shaw, Marion Schuller, Daren Fearon, Jasmin C Aschenbrenner, Peter G Marples, Grant Watt, Simon C C Lucas, Silvia Bonomo, Jennifer E Nelson, Ivan Ahel, Frank Von Delft, and Peter O'brien

Posted: 2026 February
Server: ChemRxiv
DOI: 10.26434/chemrxiv.10001784/v1

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