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Background and purposeThe development of drug resistance in Plasmodium falciparum has emerged as a major obstacle for malaria elimination programs in endemic regions, leading to their prevention failure. This poses a significant challenge for the affected population. There is a need to investigate chemotherapeutic agents with low cost and minimal toxicity to overcome drug resistance of malaria. Combination therapy is a more emerging trend guided by World Health Organization to control drug-resistant malaria. Plant-based products are readily accessible and can serve as potential complementary treatments to recommended antimalarial drugs. This review highlight importance of plant based adjuvant with their present and future clinical manifestation toward malaria control.MethodThe inclusion of a wide range of sources such as research articles, reviews, and book chapters on plant-derived combinations from the years 2010 to 2022 have been thoroughly studied and retrieved from databases such as PubMed, Google Scholar, and others.Result/ConclusionPlant-derived products have demonstrated significant success in the discovery of antimalarial drugs. By using plant extracts or phytomolecules in combination with traditional antimalarials, effective potential against malaria has been observed in vitro parasite culture with minimal safety risk and good efficacy in mice models. Several combinational antimalarial therapies have already been made available clinically, while a few others are still in clinical trial stages. Therefore, this review express recent literature on antimalarial combination therapies, highlighting their potential and providing guidance for future research in this field.