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Background: Occupational resilience (OR) is an emerging construct defined as the degree of persistence in any specified activity. Given that persistence in activities is the key determinant of both the manner and extent to which activities influence health, OR is a promising novel construct. However, there are currently no validated OR measures, making it difficult for researchers and clinicians to apply the construct. Methods: Drawing from previously published qualitative research and established theories on activity performance, the Occupational Resilience Measure (ORM 1.0) was developed and tested with graduate occupational therapy students. Subsequently, six expert clinicians evaluated the ORM using an anonymous online survey. Results: Participants determined that ORM 1.0 demonstrates validity for the construct it assesses. They also suggest that ORM 1.0 is clinically relevant and a unique evaluation instrument. Discussion: The ORM 1.0 instrument comprises 20 items, which produce an aggregate score ranging from 20 to 100, along with four subtest scores corresponding to the variables History, Experience, Benefits, and Adaptation. Subtest scores facilitate the identification of variables that exert a more pronounced impact on the overall ORM 1.0 score, allowing ORM measurements to inform intervention strategies in clinical practice. ORM scores have potential for application in predicting health outcomes in epidemiological studies. Although ORM 1.0 may need further refinement, it has considerable potential to contribute significantly to advances in clinical practice and scientific research in a unique way.