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The First Case Report of a Solitary Pulmonary Metastasis of a Transitional Meningioma and Literature Review

by SARA Di Lorenzo, Stefano Farese, Ciro Balbo, Federica Melisi, Marianna Scrima, Lucia Stefania Pasquale, Maria Pasqualina Laudato, Teresa Peluso, Domenico Solari, Andrea Ronchi, Marina Accardo, Renato Franco, Raffaele Addeo, Teresa Somma, Mario Pirozzi, Fortunato Ciardiello, Michele Caraglia, and Morena Fasano

Posted: June 12, 2025
Server: Preprints.org
DOI: 10.20944/preprints202506.1020.v1

Extracranial metastases from meningioma are extremely rare with an incidence of <1% and their prognosis is poor. Moreover, there is currently no gold standard for their treatment and, therefore, the decision making is strictly depending upon multidisciplinary discussion. In this re-port, we describe the case of a 73-year-old patient who was diagnosed with a solitary lung metas-tasis over 20 years after initial treatment for a low-grade meningioma. Molecular characterization of this metastasis was performed by Oncomine Comprehensive Assay Plus recording multiple func-tional mutations on b2microglobulin and ATM genes. A short overview of the literature is also reported. To our knowledge, no previous reports exist on single pulmonary metastasis from low-grade meningioma occurring more than 20 years after diagnosis.

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