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Si-Wu-Tang Promotes Cell Proliferation and Osteogenic Gene Expression during Osteoblastogenesis Yet Dampens the Formation of Osteoclast

by Shuenn-Yun Wu, Yu-Hsu Chen, Ming‑Te Cheng, Yu-Pao Hsu, Ying-Chou Hsieh, and Ching‑Hsiao Yu

Posted: February 29, 2024
Server: Preprints.org
DOI: 10.20944/preprints202402.1753.v1

Our results demonstrated that SWT stimulates osteoblastogenesis and increase the cell number of osteoblasts, suggesting positive regulatory effects on osteoblast differentiation. However, the effect of SWT on bone formation need further examination, since the expression of alp gene is downregulated. On the other hand, SWT appears to negatively regulate osteoclast differentiation and bone resorption, as number of osteoclasts and the expression of critical bone resorptive genes are all downregulated. Collectively, SWT might change the equilibrium of bone remodeling and increase the bone mass. Our data provided supportive evidences that this medicine formulation can be applied to treat osteoporosis or bone destructive diseases.

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