In the educational field, the importance of using resources that provide moments of interaction and promote learning spaces is demonstrated. Thus, in the development of education and the relationship between its actors (students and teachers), engaging and captivating methods are sought to enrich the minds of all involved. One of the technologies developed to date are educational games, which are continuously researched and designed ludic projects, including on a national level, considering their dual functions: fun and learning. To contribute to this research field, the board game "Poisoning Poison" is proposed to be applied in the area of Chemistry, throught it can be explored in other areas, using knowledge of toxic plants present in Brazilian territory and discoveries in the scientific field about their compounds, characteristics and harmful effects for humans. The work assumes an exploratory and qualitative approach using constant bibliographic review, investigation of existing games on the market related to plants, others produced directly for teaching chemistry and examining satisfaction when playing the board game with scientific content. The writings of Carreta (2018) in his book "Como fazer jogos de tabuleiro" were the main basis for the development of the tactical system of the board, which details the creation of space, actors, items, challenges and other components. Briefly, the game develops in three optional difficulty levels, with an extra passage at the highest level and a theme wrapped in information about 16 plants (four representing each Brazilian biome) and four mushrooms (extra interaction).