PREreviews of “Pneumococcal pneumonia in adults – Re-emergence of vaccine serotypes: a prospective multicentre cohort study in Germany, 2020-2023”

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Pneumococcal pneumonia in adults – Re-emergence of vaccine serotypes: a prospective multicentre cohort study in Germany, 2020-2023

by Christina Bahrs, Norman Rose, Grit Barten-Neiner, Carolin Fleischmann-Struzek, Mark P. G. van der Linden, Gernot Rohde, Jan Rupp, Martin Witzenrath, Jessica Rademacher, and Mathias W. Pletz

Posted: October 30, 2025
Server: medRxiv
DOI: 10.1101/2025.10.24.25338303

Abstract

This prospective multicentre study investigated pneumococcal serotype distribution and vaccine coverage of the 13- and 20-valent conjugate vaccines, and the 23-valent polysaccharide vaccine among adults with community-acquired pneumonia in Germany, from 2020 to 2023, using serotype-specific urine antigen detection testing. The findings show that Streptococcus pneumoniae has reemerged as causative pathogen of pneumonia, particularly in adults aged ≥60 years. This resurgence, observed during the ongoing SARS-CoV-2 pandemic, has been primarily driven by an increase in cases due to serotype 3.

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PREreview by Teal Lemur

Authored by Teal Lemur
Summary/Abstract:
- This preprint analyzes a multicentre study investigating pneumococcal serotype distribution and vaccine coverage of several vaccines.
- The administration of these vaccines focused on adults with community-acquired pneumonia in Germany, from 2020 to 2023, using serotype specific…
Read the PREreview by Teal Lemur

PREreviews of Pneumococcal pneumonia in adults – Re-emergence of vaccine serotypes: a prospective multicentre cohort study in Germany, 2020-2023

1 PREreview