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Hydrodynamic cavitation (HC) is increasingly used in various industrial sectors—from food and pharmaceutical production to wastewater treatment and packaging—thanks to its ability to generate shock waves and enhance extraction processes. Traditionally, circular-section Venturi tubes are employed; however, to achieve more efficient and energetically sustainable solutions, new configurations are being developed. In this study, we propose the Reuleaux Triangle (VRA) as an innovative alternative to the circular section, highlighting how its high Perimeter/Area ratio enables significantly higher pressure gradients and intensifies the cavitation phenomenon. Furthermore, both the transformation of the tube section and an optimized internal configuration, designed to reduce friction, erosion, and solid accumulation, are illustrated—thus ensuring a reliable device even under conditions of high turbulence and mechanical stress.