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Peritoneal dialysis is a therapeutic strategy for patients with renal failure due to its cost-effectiveness and ease administration. However, exposure of the peritoneal membrane to dialysis fluids triggers a remodeling process that progressively reduces treatment efficacy. Renal failure-induced protein-energy wasting further complicates therapeutic outcomes, involving nutritional and metabolic disruptions. Arthrospira maxima is a high protein and energy functional food with anti-inflammatory properties that offers a promising intervention to address these complications. This study aimed to evaluate the effects of A. maxima on protein-energy wasting and peritoneal remodeling in a uremic peritoneal dialysis model. Male Wistar rats in uremic peritoneal dialysis were divided into four groups (n=5) and fed either a 20% A. maxima-enriched diet or a standard diet for five days. Following treatment, rats were euthanized, and blood, adipose tissue, peritoneum wash, and liver imprints were obtained. The A. maxima-enriched diet modulated the immune response in the peritoneal cavity by increasing macrophage populations and reducing the recruitment of neutrophils, lymphocytes, and basophils, alongside decreased activation of the hepatic mesentery. Additionally, the enriched diet mitigated changes in energy intake, body weight, and energy reserves, demonstrating its potential to alleviate peritoneal remodeling and protein-energy wasting.