One Health, or One Health, is a concept that recognizes the interconnection between human, animal and environmental health. By bringing this approach to the educational environment, we promote a comprehensive understanding of health and well-being. This study aimed to verify studies on the relationship between secondary education and the teaching of One Health in schools, based on a literature review. The research was carried out using databases such as: Education Resources Information Center (ERIC), Redalyc Scientific Information System, Latin American and Caribbean Literature in Health Sciences (LILACS) and PUBMED, with a total of 866 articles selected and, considering inclusion and exclusion criteria, 9 were used in the review. The results indicate that, although the concept of One Health has not yet been fully internalized among educators, there are several opportunities for its integration into pedagogical practices, as well as in the use of active and participatory methodologies, allowing students to become protagonists in their learning process, and in environmental education, as an essential tool for the development of a critical and responsible awareness among students. This study concludes that the inclusion of One Health in schools can contribute to the formation of more conscious citizens, capable of facing the challenges of the globalized world. It is essential to invest in continuing education for educators and in material resources for the implementation of innovative pedagogical practices, in addition to encouraging collaboration between educational institutions and health and environmental agencies, strengthening and consolidating this approach.