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Objective: To analyze the clinical characteristics of patients with infective endocarditis (IE) admitted to a tertiary hospital in Brazil, in-hospital mortality and predictors of readmission and mortality up to six months after hospital discharge. Method: Retrospective cohort study, with data collected from medical records of patients with diagnosis of infective endocarditis hospitalized during the study period. To comparative statistical analysis patients were divided into two groups, according to the outcome: survival and death. Results: 204 patients participated in the study. Healthcare-associated infective endocarditis accounted for 62.3% of cases, with Staphylococcus aureus as the predominant pathogen. Mortality was significantly associated with complications such heart failure and septic shock (p < 0.001). Diabetes mellitus (OR 7,76; p < 0.001) and acute kidney injury (OR 7,99; p=0,016) were independent risk factors for hospital readmission (OR 7,76; p < 0.001). Overall mortality was 50.9%. Conclusion: Short-term mortality was high. Healthcare-associated infections were predominant, and complications and comorbidities significantly affect mortality in IE patients. Identifying high-risk patients and optimizing management may improve outcomes.