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This study aimed to investigate the expression levels of the iPLA2-VIA gene (FlyBase: FBgn0035800) in the nervous tissue of Drosophila melanogaster (FlyBase: FBsp00000008) larvae and adults. The gene was identified using the FlyBase database and the HGNC database. The results of our experiments indicated that the expression levels of the gene were consistent between the larval and adult stages, with higher expression of Larvae than of Adult. We also found that the gene was expressed in the CNS, digestive system, fat body, salivary glands, ovaries, and accessory glands. Furthermore, PLA2G6 (Gene ID: 8398) knockout resulted in lethality, fertility problems, tissue formation defects, and neurological abnormalities, highlighting its essential biological roles in neural health and disease. Our findings could inform future studies focused on the gene’s involvement in neural development and its potential as a therapeutic target for neurodegenerative diseases.