Structured PREreview of Mapping renal impairment and cardiac structure and function: a comprehensive analysis of prospective cohort study, Mendelian randomization and shared genetic etiology

Does the introduction explain the objective of the research presented in the preprint?

Yes

The introduction clearly outlines the objective of the research, which is to investigate the associations between renal function and cardiac parameters through cardiac magnetic resonance imaging and to explore shared genetic susceptibility.

Are the methods well-suited for this research?

Highly appropriate

The methodologies employed, including multivariable generalized linear regression, Mendelian randomization, and genetic correlation analyses, are well-suited to address the research questions posed.

Are the conclusions supported by the data?

Highly supported

The conclusion could be enhanced by providing more specific recommendations for future research, such as the applicability of these findings in diverse populations or the need for long-term monitoring of cardiac health in patients with renal impairment.

Are the data presentations, including visualizations, well-suited to represent the data?

Highly appropriate and clear

The data presentations, including tables and figures, effectively illustrate the results and make it easy for readers to understand the findings.

How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research?

Very clearly

The authors provide a thorough discussion of their findings, adequately explain the implications, and propose reasonable next steps for future research in this area.

Is the preprint likely to advance academic knowledge?

Highly likely

This preprint presents novel findings that significantly contribute to the understanding of the kidney-heart connection and may inform future research and clinical practices.

Would it benefit from language editing?

No

Would you recommend this preprint to others?

Yes, it’s of high quality

Is it ready for attention from an editor, publisher or broader audience?

Yes, after minor changes

In employing generalized linear models, it is advisable for the authors to consider socioeconomic status and physical activity as confounding factors for adjustment, as these variables could potentially influence the relationship between renal and cardiac health. The authors reference multiple studies in the discussion; however, a more in-depth comparison that highlights the similarities and differences with previous research would strengthen this section. Additionally, an expanded discussion regarding the potential clinical significance of the identified shared genetic loci could offer valuable insights for future research directions.

Competing interests

The author declares that they have no competing interests.