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Does the introduction explain the objective of the research presented in the preprint?

Yes

The introduction clearly states that the objective of the research is to define and validate a universal energetic risk threshold in cancer cells, termed the Omega Limit (Ω). It explains the theoretical background, dimensional consistency, and biological motivation for modeling the energetic overload in cells. This model aims to quantify the energetic pressure in cancer cell populations and predict their growth thresholds across various tumor types.

Are the methods well-suited for this research?

Highly appropriate

The methods used in this research are highly appropriate because they integrate dimensional analysis, theoretical modeling, and clinical data alignment. The Omega Limit model is mathematically consistent, uses SI unit validation, and defines a new energetic threshold (Ω) that is tested across multiple cancer types. This rigorous and cross-disciplinary approach supports the validity of the conclusions and reflects strong adherence to scientific methodology.

Are the conclusions supported by the data?

Highly supported

The conclusions are highly supported by the data. The theoretical Omega Limit model is validated through energy load values and clinical progression in different tumor types. The results align with existing biological literature, and the quantitative interpretation is consistent with the data.

Are the data presentations, including visualizations, well-suited to represent the data?

Somewhat inappropriate or unclear

The data are presented clearly with numerical examples and tables. While the visualizations support the findings, the clarity and labeling of graphs could be slightly improved to enhance accessibility and interpretation, especially for broader audiences.

How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research?

Somewhat unclearly

The author provides a clear interpretation of the energetic threshold model and its relevance across cancer types. However, the potential applications and future research directions could be discussed in more depth to enhance the impact and utility of the findings.

Is the preprint likely to advance academic knowledge?

Highly likely

The preprint introduces a novel energetic threshold model for cancer cells, offering a new universal constant (Ω) that helps quantify cellular energetic overload. This contribution has strong theoretical foundations and potential interdisciplinary applications, making it highly likely to advance academic understanding in oncology and systems biology.

Would it benefit from language editing?

No

The manuscript is written in a clear and technically sound manner. While there may be minor grammatical or stylistic issues, they do not interfere with the comprehension or interpretation of the scientific content.

Would you recommend this preprint to others?

Yes, it’s of high quality

Is it ready for attention from an editor, publisher or broader audience?

Yes, as it is

Competing interests

The author declares that they have no competing interests.