PREreview del Nonlinear brain connectivity from neurons to networks: quantification, sources and localization
- Publicado
- DOI
- 10.5281/zenodo.14286180
- Licencia
- CC BY 4.0
Raffaeli and colleagues present a systematic comparison of linear versus nonlinear bivariate dependency structures in the brain across spatial and temporal scales in both human and mouse.
Major issues
An old and heuristic method for computing mutual information is used (equiprobable binning) despite fast, sophisticated modern methods exist for continuous data, but these are not quantitatively compared to their binning approach. cf. https://github.com/jlizier/jidt for an open implementation.
It’s unclear whether the heuristic to decompose MI through ratios is theoretically valid.
Previous work has indeed compared linear vs. nonlinear coupling metrics in fMRI and other modalities, contrary to the statement “A principled approach for its quantification in terms of extra-Gaussian information has so far only been applied to a single modality ([10])” cf.:
Nozari et al. (2023) https://www.nature.com/articles/s41551-023-01117-y
Blinowski & Malinowski (1991): https://link.springer.com/article/10.1007/BF00243291
Zhao et al. (2013): https://ieeexplore.ieee.org/document/6542649/
Important work explaining why measured brain dynamics may become more linear (e.g., when averaging across space/time) is missing: e.g.:
Nozari et al. (2023) https://www.nature.com/articles/s41551-023-01117-y
Messe et al. (2015) http://dx.doi.org/10.1016/j.neuroimage.2015.02.001
Important context on methods for computing pairwise dependence (beyond MI and Pearson correlation) is missing, e.g.,:
Smith et al. (2011): http://linkinghub.elsevier.com/retrieve/pii/S1053811910011602
Liu et al. (2024): https://www.biorxiv.org/content/10.1101/2024.05.07.593018v1
Mohanty et al. (2020): https://www.nature.com/articles/s41598-020-57915-w
Prado et al. (2023): https://www.sciencedirect.com/science/article/pii/S096999612300061X
Cliff et al. (2023): https://www.nature.com/articles/s43588-023-00519-x
Minor issues
Concepts of “Gaussianity” and “linearity” are distinct but are not clearly distinguished (~L178), when it is important to do so.
Competing interests
The authors declare that they have no competing interests.