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Structured PREreview of Sequential deactivation across the thalamus-hippocampus-mPFC pathway during loss of consciousness

by Lawngreen Gorilla and Safa Adookkattil

Does the introduction explain the objective of the research presented in the preprint?: Yes
Are the methods well-suited for this research?: Highly appropriate; The authors used electrophysiology to determine at what time point in the experiment the subjects were unconscious. This allowed them to mark LOC in the fMRI data so they could study the physiology of multiple brain regions at the point of losing consciousness and afterwards.
Are the conclusions supported by the data?: Highly supported
Are the data presentations, including visualizations, well-suited to represent the data?: Highly appropriate and clear
How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research?: Very clearly
Is the preprint likely to advance academic knowledge?: Somewhat likely
Would it benefit from language editing?: No
Would you recommend this preprint to others?: Yes, it’s of high quality; Easy to read/understand
Is it ready for attention from an editor, publisher or broader audience?: Yes, after minor changes; A bit more clarification on how figure 5's correlograms represent synchronous activity. "This notion is further supported by an increased occurrence of synchronization in their BOLD activity before LOC and a subsequent decrease after LOC in our study, as well as in several previous studies."

The authors declare that they have no competing interests.

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