Structured PREreview of A Blueprint for Broadly Effective Bacteriophage Therapy Against Bacterial Infections

Does the introduction explain the objective of the research presented in the preprint?

Yes

Are the methods well-suited for this research?

Highly appropriate

Are the conclusions supported by the data?

Highly supported

Are the data presentations, including visualizations, well-suited to represent the data?

Highly appropriate and clear

How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research?

Very clearly

Is the preprint likely to advance academic knowledge?

Highly likely

I was interested in reading this work because it overlaps with my own (unpublished) work. I'm excited to see someone so clearly articulate things that I have had success with in my own experience working on phage complementarity for robust phage cocktails. I imagine this will be a very useful foundational reference for myself and others in the field going forward that highlights the theory and practice of executing these designs effectively.

Would it benefit from language editing?

No

Would you recommend this preprint to others?

Yes, but it needs to be improved

Having figures and legends separate makes the efficiency of reading lower than it would otherwise be in final (or near final) print format, but the formatting does not detract from the quality. I am aware that this is the preferred submission format for many journals so it should not prevent others from engaging with it at this stage, if they would prefer to engage with it now rather than waiting for peer-reviewed publication.

Is it ready for attention from an editor, publisher or broader audience?

Yes, as it is

Competing interests

I have met and discussed phage cocktail designs with the senior author, but I do not know the lead author or any of the co-authors. I was not involved with or aware of this particular work prior to publication, and did not receive any funding, authorship, or other forms of financial or professional compensation that I believe would bias my subjectivity.